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Molecular Profile | FGFR1 amp NRAS amp |
Therapy | Trametinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 amp NRAS amp | lung non-small cell carcinoma | resistant | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung carcinoma cells harboring both FGFR1 and NRAS amplification were resistant to Mekinist (trametinib) in culture (PMID: 28630215). | 28630215 |
PubMed Id | Reference Title | Details |
---|---|---|
(28630215) | Mechanisms of Primary Drug Resistance in FGFR1-Amplified Lung Cancer. | Full reference... |