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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D820Y | melanoma | resistant | Imatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Gleevec (imatinib mesylate) failed to inhibit MNK pathway activation and proliferation of melanoma cell lines harboring KIT D820Y in culture (PMID: 29035277). | 29035277 |
PubMed Id | Reference Title | Details |
---|---|---|
(29035277) | MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. | Full reference... |