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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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KIT D820Y | melanoma | sensitive | SEL201 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SEL201 inhibited MNK pathway signaling and growth of melanoma cell lines harboring KIT D820Y in culture, and suppressed tumor metastasis in xenograft models (PMID: 29035277). | 29035277 |
PubMed Id | Reference Title | Details |
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(29035277) | MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. | Full reference... |