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| Molecular Profile | KIT V560G KIT D816V |
| Therapy | Avapritinib |
| Indication/Tumor Type | mast-cell leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560G KIT D816V | mast-cell leukemia | sensitive | Avapritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Ayvakit (avapritinib) inhibited Kit phosphorylation and proliferation of a mast cell leukemia cell line harboring KIT D816V and V560G in culture (PMID: 29093181). | 29093181 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29093181) | A precision therapy against cancers driven by KIT/PDGFRA mutations. | Full reference... |