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Molecular Profile | KIT V560G |
Therapy | Avapritinib |
Indication/Tumor Type | mast-cell leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560G | mast-cell leukemia | sensitive | Avapritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Ayvakit (avapritinib) inhibited Kit phosphorylation and proliferation of mast cell leukemia cells harboring KIT V560G in culture (PMID: 29093181). | 29093181 |
PubMed Id | Reference Title | Details |
---|---|---|
(29093181) | A precision therapy against cancers driven by KIT/PDGFRA mutations. | Full reference... |