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Molecular Profile | PIK3CA E545K |
Therapy | Pictilisib + Sorafenib |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545K | urinary bladder cancer | sensitive | Pictilisib + Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Pictilisib (GDC-0941) and Nexavar (sorafenib) synergistically decreased Erk and Akt phosphorylation, inhibited survival of bladder cancer cells harboring PIK3CA E545K in culture (PMID: 28808038). | 28808038 |
PubMed Id | Reference Title | Details |
---|---|---|
(28808038) | The Phosphatidylinositol 3-Kinase Pathway as a Potential Therapeutic Target in Bladder Cancer. | Full reference... |