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| Molecular Profile | FGFR1 amp |
| Therapy | Pazopanib |
| Indication/Tumor Type | Her2-receptor negative breast cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 amp | Her2-receptor negative breast cancer | predicted - sensitive | Pazopanib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with ERBB2 (HER2)-receptor negative breast cancer harboring FGFR1 amplification demonstrated antitumor activity when treated with Votrient (pazopanib), including a near complete loss of brain lesions and improved function of the liver (PMID: 29223982). | 29223982 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29223982) | Pazopanib Sensitivity in a Patient With Breast Cancer and FGFR1 Amplification. | Full reference... |