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Molecular Profile | FGFR2 amp |
Therapy | Fexagratinib |
Indication/Tumor Type | gastric adenocarcinoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp | gastric adenocarcinoma | no benefit | Fexagratinib | Phase II | Actionable | In a Phase II trial (SHINE), AZD4547 treatment did not improve progression-free survival compared to Taxol (paclitaxel) (1.8 vs 3.5 months, p=0.9581) in advanced gastric adenocarcinoma patients with FGFR2 amplification (PMID: 29177434; NCT01457846). | 29177434 |
PubMed Id | Reference Title | Details |
---|---|---|
(29177434) | A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification. | Full reference... |