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Molecular Profile | BRAF V600E |
Therapy | Sorafenib |
Indication/Tumor Type | melanoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | melanoma | no benefit | Sorafenib | Phase II | Actionable | In a Phase II study, Nexavar (sorafenib) displayed negligible efficacy in melanoma patients with BRAF V600E mutations (PMID: 16880785, PMID: 22394203). | 22394203 16880785 |
PubMed Id | Reference Title | Details |
---|---|---|
(22394203) | Sorafenib in melanoma. | Full reference... |
(16880785) | Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. | Full reference... |