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Molecular Profile | TP53 over exp |
Therapy | HLA-A2 p53:264-272 vaccine |
Indication/Tumor Type | ovarian cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 over exp | ovarian cancer | predicted - sensitive | HLA-A2 p53:264-272 vaccine | Phase I | Actionable | In a Phase I trial, the HLA-A2 p53:264-272 vaccine demonstrated safety and preliminary efficacy in patients with TP53 overexpressing ovarian cancer, resulting in a progression-free survival of 5.5 months and an overall survival of 40.4 months (PMID: 21927947). | 21927947 |
PubMed Id | Reference Title | Details |
---|---|---|
(21927947) | A gynecologic oncology group phase II trial of two p53 peptide vaccine approaches: subcutaneous injection and intravenous pulsed dendritic cells in high recurrence risk ovarian cancer patients. | Full reference... |