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| Molecular Profile | CHEK1 over exp |
| Therapy | PF-00477736 |
| Indication/Tumor Type | lung small cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CHEK1 over exp | lung small cell carcinoma | sensitive | PF-00477736 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, small cell lung cancer cell lines, which expressed high levels of CHEK1, demonstrated sensitivity to PF-00477736 treatment, resulting in decreased viability in culture and reduced tumor growth in xenograft models (PMID: 29138515). | 29138515 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29138515) | Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer. | Full reference... |