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Molecular Profile | ALK G1123D ALK F1174L |
Therapy | TAE684 |
Indication/Tumor Type | neuroblastoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK G1123D ALK F1174L | neuroblastoma | resistant | TAE684 | Preclinical - Cell culture | Actionable | In a preclinical study, expression of ALK G1123D in neuroblastoma cells harboring an ALK F1174L mutation resulted in resistance to TAE684 in culture (PMID: 21948233). | 21948233 |
PubMed Id | Reference Title | Details |
---|---|---|
(21948233) | ALK mutations conferring differential resistance to structurally diverse ALK inhibitors. | Full reference... |