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| Molecular Profile | HRAS G12V |
| Therapy | SR9009 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS G12V | Advanced Solid Tumor | predicted - sensitive | SR9009 | Preclinical - Cell culture | Actionable | In a preclinical study, SR9009 treatment resulted in apoptosis in HRAS G12V-induced senescent firbroblast cells in culture (PMID: 29320480). | 29320480 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29320480) | Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. | Full reference... |