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Molecular Profile | HRAS G12V |
Therapy | SR9011 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS G12V | Advanced Solid Tumor | predicted - sensitive | SR9011 | Preclinical - Cell culture | Actionable | In a preclinical study, SR9011 treatment resulted in apoptosis in HRAS G12V-induced senescent firbroblast cells in culture (PMID: 29320480). | 29320480 |
PubMed Id | Reference Title | Details |
---|---|---|
(29320480) | Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. | Full reference... |