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Molecular Profile | ALK negative |
Therapy | CEP-28122 |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK negative | lung non-small cell carcinoma | resistant | CEP-28122 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ALK negative non-small cell lung carcinoma cells were resistant to CEP-28122 in culture and in cell line xenograft models (PMID: 22203728). | 22203728 |
PubMed Id | Reference Title | Details |
---|---|---|
(22203728) | CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. | Full reference... |