Profile Response Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
NTRK2 fusion	Advanced Solid Tumor	sensitive	Larotrectinib	Clinical Study - Cohort	Actionable	In a combined analysis of three trials, Vitrakvi (larotrectinib) resulted in improved median overall survival (39.7 vs 10.2 months) and a 78% lower risk of death (HR=0.22, P=0.001) compared to standard of care treatment in patients with advanced solid tumors harboring NTRK fusions (PMID: 36689698; NCT02122913, NCT02637687, and NCT02576431).	36689698
NTRK2 fusion	Advanced Solid Tumor	sensitive	Larotrectinib	Phase Ib/II	Actionable	In a Phase I/II trial, Vitrakvi (larotrectinib) treatment resulted in complete response in 26.7% (4/15), partial response in 66.7% (10/15), and stable disease in 6.7% (1/15) of pediatric patients with advanced solid tumors harboring NTRK fusions, and progressive diseases in all 7 patients without NTRK fusions (PMID: 29606586; NCT02637687).	29606586
NTRK2 fusion	Advanced Solid Tumor	sensitive	Larotrectinib	FDA approved	Actionable	In three trials that supported FDA approval, Vitrakvi (larotrectinib) treatment resulted in an overall response rate of 75% (41/55) in adult and pediatric patients with advanced solid tumors harboring either an NTRK1, NTRK2, or NTRK3 fusion, including 7 patients achieving a complete response and 34 patients achieving a partial response (PMID: 29466156; NCT02122913, NCT02637687, NCT02576431).	detail... 29466156

PubMed Id	Reference Title	Details
(29466156)	Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.	Full reference...
(29606586)	Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.	Full reference...
	Vitrakvi (larotrectinib) FDA Drug Label	Full reference...
(36689698)	Survival Outcomes of Patients With Tropomyosin Receptor Kinase Fusion-Positive Cancer Receiving Larotrectinib Versus Standard of Care: A Matching-Adjusted Indirect Comparison Using Real-World Data.	Full reference...