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| Molecular Profile | PBRM1 N609fs |
| Therapy | Nivolumab |
| Indication/Tumor Type | clear cell renal cell carcinoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PBRM1 N609fs | clear cell renal cell carcinoma | no benefit | Nivolumab | Case Reports/Case Series | Actionable | In a clinical study, Opdivo (nivolumab) treatment resulted in progressive disease in a patient with renal clear cell carcinoma harboring PBRM1 N609fs (PMID: 29301960). | 29301960 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29301960) | Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. | Full reference... |