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Molecular Profile | JAK2 V617F |
Therapy | BMS-911543 |
Indication/Tumor Type | myeloproliferative neoplasm |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | myeloproliferative neoplasm | sensitive | BMS-911543 | Preclinical - Cell culture | Actionable | In a preclinical study, BMS-911543 inhibited colony growth in myeloproliferative neoplasm patient-derived hematopoetic progenitor cells harboring JAK2 V617F in culture (PMID: 22015772). | 22015772 |
PubMed Id | Reference Title | Details |
---|---|---|
(22015772) | Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. | Full reference... |