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Molecular Profile FGFR2 fusion FGFR2 amp
Therapy Derazantinib
Indication/Tumor Type stomach cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 fusion FGFR2 amp stomach cancer sensitive Derazantinib Preclinical - Cell line xenograft Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited Fgfr signaling and growth of gastric cancer cells harboring FGFR2 amplification and PDHX-FGFR2 fusion in culture, resulted in tumor regression in cell line xenograft models (PMID: 27627808). 27627808
PubMed Id Reference Title Details
(27627808) Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation. Full reference...