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| Molecular Profile | TP53 mutant |
| Therapy | GDC-0575 + Gemcitabine |
| Indication/Tumor Type | fibrous histiocytoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 mutant | fibrous histiocytoma | predicted - sensitive | GDC-0575 + Gemcitabine | Preclinical - Pdx | Actionable | In a preclinical study, GDC-0575 and Gemzar (gemcitabine) combination treatment inhibited tumor growth, prolonged progression-free survival in patient-derived xenogrft (PDX) models of undifferentiated pleomorphic sarcoma (fibrous histiocytoma) (PMID: 29409053). | 29409053 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29409053) | CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. | Full reference... |