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| Molecular Profile | TP53 mutant |
| Therapy | GDC-0575 + Gemcitabine |
| Indication/Tumor Type | sarcoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 mutant | sarcoma | predicted - sensitive | GDC-0575 + Gemcitabine | Phase I | Actionable | In a Phase I trial, GDC-0575 and Gemzar (gemcitabine) combination treatment resulted in a prolonged tumor response in 2 soft tissue sarcoma patients harboring TP53 mutations, and no response in a patient with TP53 wild-type tumor (PMID: 29409053; NCT01564251). | 29409053 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29409053) | CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. | Full reference... |