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Molecular Profile | PIK3CA E453K |
Therapy | Buparlisib |
Indication/Tumor Type | breast cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E453K | breast cancer | resistant | Buparlisib | Preclinical - Cell culture | Actionable | In a preclinical study, breast cancer cells expressing PIK3CA E453K demonstrated resistance to treatment with Buparlisib (BKM120) in culture (PMID: 29636477). | 29636477 |
PubMed Id | Reference Title | Details |
---|---|---|
(29636477) | Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. | Full reference... |