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| Molecular Profile | PIK3CA E545K |
| Therapy | Buparlisib |
| Indication/Tumor Type | breast cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | breast cancer | resistant | Buparlisib | Preclinical - Cell culture | Actionable | In a preclinical study, breast cancer cells expressing PIK3CA E545K demonstrated resistance to treatment with Buparlisib (BKM120) in culture (PMID: 29636477). | 29636477 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29636477) | Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. | Full reference... |