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Molecular Profile | TP53 R248Q |
Therapy | ALRN-6924 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R248Q | acute myeloid leukemia | resistant | ALRN-6924 | Preclinical - Cell culture | Actionable | In a preclinical study, ALRN-6924 did not inhibit the growth of acute myeloid leukemia cells harboring TP53 R248Q in culture (PMID: 29643228). | 29643228 |
PubMed Id | Reference Title | Details |
---|---|---|
(29643228) | Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. | Full reference... |