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Molecular Profile NTRK1 fusion
Therapy Larotrectinib
Indication/Tumor Type gastrointestinal system cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 fusion gastrointestinal system cancer predicted - sensitive Larotrectinib Phase I Actionable In a combined analysis of 3 clinical trials, Vitrakvi (larotrectinib) treatment resulted in an objective response rate of 75% (8/12, 1 complete response, 7 partial responses) in patients with gastrointestinal system malignancies harboring NTRK fusions, including colon cancer, pancreatic carcinoma, cholangiocarcinoma and GIST, and stable disease in 3 patients, with duration of response ranging from 3.5 to 22.9 months (Annals of Oncology, Volume 29, Issue suppl_5; NCT02122913, NCT02637687, and NCT02576431). detail...
NTRK1 fusion gastrointestinal system cancer predicted - sensitive Larotrectinib Phase II Actionable In a Phase II trial (NAVIGATE), Vitrakvi (larotrectinib) treatment resulted in an overall response rate (ORR) of 28% (12/43, 3 complete and 9 partial responses) and stable disease in 44% (19/43) of gastrointestinal cancer patients harboring NTRK fusions, with a median duration of response of 27 mo, median progression-free survival of 6 mo, and median overall survival of 13 mo; ORR was 38% (10/26) in patients with NTRK1 fusions (PMID: 40068370; NCT02576431). 40068370
PubMed Id Reference Title Details
O-020 - Activity of larotrectinib in patients with TRK fusion GI malignancies Full reference...
(40068370) Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer. Full reference...