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Molecular Profile | NRAS mutant |
Therapy | Adavosertib |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS mutant | melanoma | sensitive | Adavosertib | Preclinical | Actionable | In a preclinical study, Adavosertib (MK-1775) showed efficacy in NRAS mutant melanoma and in mutant KRAS colorectal, pancreatic, and lung cancers (PMID: 24791855). | 24791855 |
PubMed Id | Reference Title | Details |
---|---|---|
(24791855) | Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. | Full reference... |