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Molecular Profile | BRAF Y472C |
Therapy | Dasatinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF Y472C | lung non-small cell carcinoma | sensitive | Dasatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Sprycel (dasatinib) induced apoptosis in non-small cell lung carcinoma cells harboring BRAF Y472C in culture (PMID: 22649091). | 22649091 |
PubMed Id | Reference Title | Details |
---|---|---|
(22649091) | Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. | Full reference... |