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Molecular Profile TP53 P72R TP53 Y220C
Therapy Cyclophosphamide + Epirubicin
Indication/Tumor Type breast cancer
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P72R TP53 Y220C breast cancer no benefit Cyclophosphamide + Epirubicin Phase I Actionable In a Phase I clinical trial, a breast cancer patient carrying TP53 P72R and Y220C mutations demonstrated incomplete response to treatment with an Ellence (epirubicin)-Cytoxan (cyclophosphamide) combination regimen (PMID: 17388661). 17388661
PubMed Id Reference Title Details
(17388661) Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. Full reference...