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Molecular Profile FBXW7 mutant
Therapy LY3039478
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FBXW7 mutant Her2-receptor negative breast cancer predicted - sensitive LY3039478 Case Reports/Case Series Actionable In a Phase I trial, LY3039478 treatment resulted in partial response lasted 9.5 months in a patient with hormone receptor-positive, Erbb2 (Her2)-negative breast cancer harboring FBXW7 mutation (PMID: 30060061; NCT01695005). 30060061
PubMed Id Reference Title Details
(30060061) First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer. Full reference...