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Molecular Profile | BRAF L514V BRAF V600E |
Therapy | BGB3245 |
Indication/Tumor Type | melanoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF L514V BRAF V600E | melanoma | predicted - sensitive | BGB3245 | Preclinical - Cell culture | Actionable | In a preclinical study, BGB3245 resulted in similar inhibition of Erk phosphorylation and colony formation in melanoma cells expressing BRAF L514V in cis with V600E and cells expressing BRAF V600E alone in culture (PMID: 29880583). | 29880583 |
PubMed Id | Reference Title | Details |
---|---|---|
(29880583) | A Secondary Mutation in BRAF Confers Resistance to RAF Inhibition in a BRAFV600E-Mutant Brain Tumor. | Full reference... |