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Molecular Profile | ARID1A dec exp |
Therapy | Molibresib |
Indication/Tumor Type | ovarian clear cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A dec exp | ovarian clear cell carcinoma | predicted - sensitive | Molibresib | Preclinical - Cell culture | Actionable | In a preclinical study, knockdown of ARID1A resulted in increased sensitivity to Molibresib (GSK525762) in ovarian clear cell carcinoma cell lines in culture (PMID: 29760405). | 29760405 |
PubMed Id | Reference Title | Details |
---|---|---|
(29760405) | ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors. | Full reference... |