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| Molecular Profile | KDR L840F |
| Therapy | Regorafenib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KDR L840F | colorectal cancer | resistant | Regorafenib | Preclinical - Pdx | Actionable | In a preclinical study, a metastatic colorectal cancer patient-derived xenograft (PDX) model harboring KDR (VEGFR2) L840F did not respond to treatment with Stivarga (regorafenib) (PMID: 29588308). | 29588308 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29588308) | Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies. | Full reference... |