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| Molecular Profile | BRAF V600E MAP2K1 K57T |
| Therapy | Cobimetinib + Vemurafenib |
| Indication/Tumor Type | refractory hairy cell leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E MAP2K1 K57T | refractory hairy cell leukemia | predicted - sensitive | Cobimetinib + Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with hairy cell leukemia harboring BRAF V600E who relapsed after initial response to Zelboraf (vemurafenib) and was found to have acquired multiple clones with Mek/Erk activating mutations, including MAP2K1 K57T, demonstrated a sustained response greater than 12 months to combined Zelboraf (vemurafenib) and Cotellic (cobimetinib) treatment (PMID: 30341394). | 30341394 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30341394) | Targeting MEK in vemurafenib-resistant hairy cell leukemia. | Full reference... |