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| Molecular Profile | BRAF V600E MAP2K1 K57T |
| Therapy | Vemurafenib |
| Indication/Tumor Type | hairy cell leukemia |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E MAP2K1 K57T | hairy cell leukemia | predicted - resistant | Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, a single patient with hairy cell leukemia harboring BRAF V600E, who relapsed after a 38 week remission in response to Zelboraf (vemurafenib) treatment, was found to have acquired multiple clones with Mek/Erk activating mutations, of which the MAP2K1 K57T clone became dominant (PMID: 30341394). | 30341394 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30341394) | Targeting MEK in vemurafenib-resistant hairy cell leukemia. | Full reference... |