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Molecular Profile | KEAP1 mutant |
Therapy | Radiotherapy |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KEAP1 mutant | lung non-small cell carcinoma | predicted - resistant | Radiotherapy | Clinical Study - Cohort | Actionable | In a clinical study, non-small cell lung cancer patients harboring KEAP1 or NFE2L2 mutations (n=9) demonstrated higher incidence of local recurrence at 30-months after radiotherapy (70% vs 18%, p<0.003) compared to KEAP1/NFE2L2 wild-type patients (n=33) (PMID: 27663899). | 27663899 |
PubMed Id | Reference Title | Details |
---|---|---|
(27663899) | Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance. | Full reference... |