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| Molecular Profile | DNMT3A mutant |
| Therapy | Pinometostat |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| DNMT3A mutant | acute myeloid leukemia | sensitive | Pinometostat | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Pinometostat (EPZ-5676) treatment of acute myeloid leukemia cell lines and xenografts resulted in apoptosis, cell-cycle arrest, and terminal differentiation (PMID: 27335278). | 27335278 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27335278) | DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. | Full reference... |