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Molecular Profile | TP53 P72R |
Therapy | Doxorubicin + Ifosfamide |
Indication/Tumor Type | sarcoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 P72R | sarcoma | sensitive | Doxorubicin + Ifosfamide | Phase I | Actionable | In a Phase I clinical trial, sarcoma patients harboring TP53 P72R mutations had longer progression-free survival after treatment with Cyfos (ifosfamide) and Adriamycin (doxorubicin) (PMID: 23165797). | 23165797 |
PubMed Id | Reference Title | Details |
---|---|---|
(23165797) | Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma. | Full reference... |