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Molecular Profile | IDH1 R132H |
Therapy | Decitabine |
Indication/Tumor Type | oligodendroglioma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | oligodendroglioma | sensitive | Decitabine | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Dacogen (decitabine) decreased colony formation and tumor growth in patient derived xenograft (PDX) models of patient derived oligodendroglioma cells with IDH1 R132H mutations and co-deletion of 1p and 19q (PMID: 24077826). | 24077826 |
PubMed Id | Reference Title | Details |
---|---|---|
(24077826) | Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. | Full reference... |