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Molecular Profile | IDH1 R132H |
Therapy | Azacitidine |
Indication/Tumor Type | anaplastic astrocytoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | anaplastic astrocytoma | sensitive | Azacitidine | Preclinical | Actionable | In a preclinical study, long-term treatment with Vidaza (azacitidine) resulted in increased cellular differentiation, decreased proliferation, and tumor regression in a patient-derived xenograft (PDX) model of anaplastic astrocytoma harboring IDH1 R132H (PMID: 24077805). | 24077805 |
PubMed Id | Reference Title | Details |
---|---|---|
(24077805) | 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. | Full reference... |