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Molecular Profile TP53 del
Therapy Tanespimycin
Indication/Tumor Type colorectal cancer
Response Type decreased response

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 del colorectal cancer decreased response Tanespimycin Preclinical Actionable In a preclincal study, Tanespimycin (17-AAG) treatment of mutagen induced colorectal cancer in a genetic mouse model with biallelic loss of TP53 was less effective than treatment of mice bearing a single allele with a TP53 R248Q mutation (PMID: 30107178). 30107178
PubMed Id Reference Title Details
(30107178) Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. Full reference...