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Molecular Profile | FGFR1 V561M |
Therapy | Fexagratinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 V561M | lung non-small cell carcinoma | resistant | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells expressing FGFR1 V561M demonstrated resistance to AZD4547 in culture (PMID: 30257990). | 30257990 |
PubMed Id | Reference Title | Details |
---|---|---|
(30257990) | The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT. | Full reference... |