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| Molecular Profile | TP53 R248Q |
| Therapy | Napabucasin |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R248Q | colorectal cancer | predicted - sensitive | Napabucasin | Preclinical - Cell culture | Actionable | In a preclinical study, Napabucasin (BBI608) treatment reduced Stat3 phosphorylation and impaired wound healing in colorectal cancer cell lines expressing TP53 R248Q in culture (PMID: 30107178). | 30107178 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30107178) | Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. | Full reference... |