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| Molecular Profile | MERTK positive |
| Therapy | UNC569 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MERTK positive | acute myeloid leukemia | sensitive | UNC569 | Preclinical - Cell culture | Actionable | In a preclinical study, UNC569 inhibited Mertk phosphorylation and downstream signaling, resulted in growth inhibition of acute myeloid leukemia cell lines in culture (PMID: 29277773). | 29277773 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29277773) | Effects of MERTK Inhibitors UNC569 and UNC1062 on the Growth of Acute Myeloid Leukaemia Cells. | Full reference... |