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| Molecular Profile | TP53 inact mut |
| Therapy | Adavosertib + Radiotherapy |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 inact mut | breast cancer | sensitive | Adavosertib + Radiotherapy | Preclinical | Actionable | In a preclinical study, Adavosertib (MK-1775) increased the efficacy of radiation in breast cancer cells with defective TP53 in culture (PMID: 21799033). | 21799033 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21799033) | MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. | Full reference... |