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Molecular Profile | MDM2 amp |
Therapy | unspecified MDM2 inhibitor |
Indication/Tumor Type | liposarcoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MDM2 amp | liposarcoma | predicted - sensitive | unspecified MDM2 inhibitor | Phase I | Actionable | In a Phase I trial, treatment with an unspecified MDM2 inhibitor resulted in clinical efficacy in six patients with liposarcoma harboring MDM2 amplification, including three patients with a partial response and two patients with stable disease for 15.7 months and 4.7 months (PMID: 30237864). | 30237864 |
PubMed Id | Reference Title | Details |
---|---|---|
(30237864) | Prevalence of MDM2 amplification and coalterations in 523 advanced cancer patients in the MD Anderson phase 1 clinic. | Full reference... |