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| Molecular Profile | CSF1R positive |
| Therapy | NMS-P088 |
| Indication/Tumor Type | chronic myelomonocytic leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CSF1R positive | chronic myelomonocytic leukemia | predicted - sensitive | NMS-P088 | Preclinical - Patient cell culture | Actionable | In a preclinical study, NMS-P088 inhibited proliferation of Csf1r-expressing blasts derived from chronic myelomonocytic leukemia patients (Proceedings of the American Association for Cancer Research, Vol 60, Mar 2019, Abstract #1324). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| NMS-P088, a novel FLT3, KIT and CSF1R inhibitor, is a promising clinical candidate for AML and CMML treatment. | Full reference... |