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| Molecular Profile | RET mutant |
| Therapy | Ponatinib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET mutant | colorectal cancer | sensitive | Ponatinib | Preclinical | Actionable | In a preclinical study, Iclusig (ponatinib) demonstrated efficacy in RET mutant positive colorectal cancer cell lines (PMID: 23811235). | 23811235 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23811235) | Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase. | Full reference... |