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Molecular Profile | BRAF K601E MAP2K1 V211D |
Therapy | Binimetinib + Cetuximab |
Indication/Tumor Type | colon cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF K601E MAP2K1 V211D | colon cancer | resistant | Binimetinib + Cetuximab | Preclinical - Pdx | Actionable | In a preclinical study, Mektovi (binimetinib) and Erbitux (cetuximab) combination did not inhibit Rsk and Erk phosphorylation, and had no effect on tumor growth in patient-derived xenograft (PDX) models of metastatic colon cancer harboring BRAF K601E and MAP2K1 V211D (PMID: 31227518). | 31227518 |
PubMed Id | Reference Title | Details |
---|---|---|
(31227518) | V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. | Full reference... |