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Molecular Profile ATM V410A
Therapy Temozolomide + Veliparib
Indication/Tumor Type lung small cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM V410A lung small cell carcinoma predicted - sensitive Temozolomide + Veliparib Case Reports/Case Series Actionable In a Phase II trial, Temodar (temozolomide) and Veliparib (ABT-888) combination treatment resulted stable disease in a patient with small cell lung cancer harboring ATM V410A, with a progression-free survival of 6.3 months and an overall survival of 6.3 months (PMID: 29906251; NCT01638546). 29906251
PubMed Id Reference Title Details
(29906251) Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer. Full reference...