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Molecular Profile | APC inact mut |
Therapy | Sirolimus |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colon cancer | sensitive | Sirolimus | Preclinical | Actionable | In preclinical trials, Sirolimus (rapamycin) was shown effective in reducing tumors in mouse models of familial adenomatous polyposis and colon cancer with APC deficient tumors (PMID: 18768809, PMID: 20080688). | 18768809 20080688 |
PubMed Id | Reference Title | Details |
---|---|---|
(18768809) | Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. | Full reference... |
(20080688) | Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. | Full reference... |